[HGH response to insulin-induced hypoglycemia in healthy subjects and obesity].

jects. The following results were obtained: 1. The fasting level of HGH and HGH response to insulin-induced hypoglycemia are different with sex, age and the presence of obesity. 2. HGH response to insulin-induced hypoglycemia in standard weight healthy subjects aged in 20-29 was as follows: (M+SE, mpg/m1) fasting 15' 30' 45' 60' 120' 180 male 4.4+1.6 7.4+2.0 28.8+5.2 66.0±6.4 70.6±6.3 36.0±6.4 9.2+1.7 female 9.6+1.5 6.2+1.1 15.4±2.3 38.3±6.4 32.0±5.6 14.1+4.1 3.2±0.4 3. It was observed that the fasting level of HGH was higher in the female than in the male, but in subjects over 45 years of age no difference was observed between the female and the male. 4. HGH response to insulin-induced hypoglycemia was significantly higher in the male aged in 20-29 than in the male aged over 30 and in the female of all age groups. In the group over 30 years of age, difference between the male and, the female was not clear. 5. There was not a significant correlation between HGH response and insulin sensitivity index, minimum plasma glucose level or FFA decrement. There was, however, a significant correlation between FFA increment from 60 to 180 minutes after an insulin injection and HGH response. (r=0.71, P<0.005) 6. It was observed that HGH response was lower in obese subjects than in standard weight healthy subjects, both the male and the female. It appears likely that obese subjects require less HGH for fat mobilization than standard weight healthy subjects. (See pp. 443-.454)